Interferon regulatory factor 2-binding protein 1

Definition:

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.

References:

[1]. Kay S Childs, et al. Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. Nucleic Acids Res. 2003 Jun 15;31(12):3016-26. [Content Brief]

[2]. Makoto Kimura, et al. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. FEBS Lett. 2008 Aug 20;582(19):2833-7. [Content Brief]

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