Interleukin-1 receptor associated kinase 4 (IRAK4)

Definition:

Interleukin-1 receptor-associated kinase 4 (IRAK4) is the most upstream kinase in Toll/Interleukin-1 receptor (TIR) signaling. IRAK4 also take part in TIR signaling with IRAK1, IRAK2, and IRAK3 (also called IRAKM) together. IRAK4 can be used for the research of immune response.

References:

[1]. William T McElroy, et al. Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors: an updated patent review (2016-2018). Expert Opin Ther Pat. 2019 Apr;29(4):243-259. [Content Brief]

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