Interleukin-18 receptor 1

Definition:

Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

References:

[1]. Zenichiro Kato, et al. The structure and binding mode of interleukin-18. Nat Struct Biol. 2003 Nov;10(11):966-71. [Content Brief]

[2]. Naotaka Tsutsumi, et al. The structural basis for receptor recognition of human interleukin-18. Nat Commun. 2014 Dec 15;5:5340. [Content Brief]

[3]. Hui Wei, et al. Structural basis for the specific recognition of IL-18 by its alpha receptor. FEBS Lett. 2014 Nov 3;588(21):3838-43. [Content Brief]

[4]. K Tominaga, et al. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int Immunol. 2000 Feb;12(2):151-60. [Content Brief]

[5]. P Parnet, et al. IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem. 1996 Feb 23;271(8):3967-70. [Content Brief]

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