Ion Mobility Mass Spectrometry of Complexes

Definition:

Ion Mobility Mass Spectrometry of Complexes is a method that combines ion mobility technology and mass spectrometry to analyze the size, shape, and mass of protein complexes. First, the target protein complex is ionized, then separated based on their cross-section and charge-to-mass ratio (Q/z) through ion mobility, and finally analyzed by mass spectrometry for their mass-to-charge ratio (m/z). This technique is particularly useful for studying the three-dimensional structure and dynamics of large molecular complexes, as well as for screening and validating drug binding modes with target proteins in drug development.

References:

[1]. Ruotolo BT, et al. Ion mobility-mass spectrometry analysis of large protein complexes. Nat Protoc. 2008;3(7):1139-52. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.