Katanin p60 ATPase-containing subunit A1

Definition:

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

References:

[1]. Dan Buster, et al. Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis. J Cell Sci. 2002 Mar 1;115(Pt 5):1083-92. [Content Brief]

[2]. Subbareddy Maddika, et al. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol. 2009 Apr;11(4):409-19. [Content Brief]

[3]. K P McNally, et al. Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. J Cell Sci. 2000 May;113 ( Pt 9):1623-33. [Content Brief]

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