Lacrimal duct defect

Definition:

Lacrimal duct defect (LCDD) is a congenital disease characterized by lacrimal duct partial absence or total lacrimal duct absence. LCDD is one of the causes of epiphora in infants and adolescents. Mutations in IGSF3 gene have been found in the patients with congenital absence of lacrimal puncta and canaliculi.

References:

[1]. Fei Wang, et al. Preliminary report on screening IGSF3 gene mutation in families with congenital absence of lacrimal puncta and canaliculi. Int J Ophthalmol. 2020 Sep 18;13(9):1351-1355. [Content Brief]

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