Legg-Calve-Perthes Disease

Definition:

Legg-Calve-Perthes disease (LCPD) is a particular type of femoral head necrosis occurring in children. It is more common among boys, and bilateral involvement occurs in 8-24% of cases. The disease is usually diagnosed among children under age 14 years, with a peak onset between 5 and 8 years of age. There is delayed skeletal maturation and impaired growth. In addition to congenital abnormalities, LCPD is associated with greater risk of cardiovascular diseases and diseases of the blood. Most cases are sporadic, but familial cases have been described. It has been reported that COL2A1 mutations are associated with this disease.

References:

[1]. Megan L Young, et al. Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease. Clin Orthop Relat Res. 2012 Sep;470(9):2462-75. [Content Brief]

[2]. Teena Bansal, et al. Legg-Calve-Perthes disease: A must know entity for anaesthesiologists. Indian J Anaesth. 2016 Jan;60(1):68-9. [Content Brief]

[3]. Yoshinari Miyamoto, et al. A recurrent mutation in type II collagen gene causes Legg-Calvé-Perthes disease in a Japanese family. Hum Genet. 2007 Jun;121(5):625-9. [Content Brief]

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