Leucine zipper transcription factor-like protein 1

Definition:

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.

References:

[1]. Qun Wei, et al. Tumor-suppressive functions of leucine zipper transcription factor-like 1. Cancer Res. 2010 Apr 1;70(7):2942-50. [Content Brief]

[2]. Seongjin Seo, et al. A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genet. 2011 Nov;7(11):e1002358. [Content Brief]

[3]. Vincent Marion, et al. Exome sequencing identifies mutations in LZTFL1, a BBSome and smoothened trafficking regulator, in a family with Bardet--Biedl syndrome with situs inversus and insertional polydactyly. J Med Genet. 2012 May;49(5):317-21. [Content Brief]

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