Leukocyte-specific transcript 1 protein

Definition:

Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.

References:

[1]. I Rollinger-Holzinger, et al. LST1: a gene with extensive alternative splicing and immunomodulatory function. J Immunol. 2000 Mar 15;164(6):3169-76. [Content Brief]

[2]. A Raghunathan, et al. Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells. Exp Cell Res. 2001 Aug 15;268(2):230-44. [Content Brief]

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