Leukosialin

Definition:

Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity).; [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival.

References:

[1]. Oscar Ramírez-Pliego, et al. CD43 signals induce Type One lineage commitment of human CD4+ T cells. BMC Immunol. 2007 Nov 23;8:30. [Content Brief]

[2]. A O Galindo-Albarrán, et al. CD43 signals prepare human T cells to receive cytokine differentiation signals. J Cell Physiol. 2014 Feb;229(2):172-80. [Content Brief]

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