LexA VP16 Transcription Complementation

Definition:

LexA VP16 Transcription Complementation uses the yeast two-hybrid system, combining the Escherichia coli LexA amino acids 1-202 as the DNA-binding domain and the transcriptional activation domain from the herpes simplex virus protein VP16 to specifically activate the transcription of a downstream reporter gene. This method is particularly important in protein-protein interaction and gene regulation research.

References:

[1]. Alifragis P, et al. A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13099-104. [Content Brief]

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