LINE-1 retrotransposable element ORF1 protein

Definition:

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

References:

[1]. J V Moran, et al. High frequency retrotransposition in cultured mammalian cells. Cell. 1996 Nov 29;87(5):917-27. [Content Brief]

[2]. W Wei, et al. Human L1 retrotransposition: cis preference versus trans complementation. Mol Cell Biol. 2001 Feb;21(4):1429-39. [Content Brief]

[3]. Zbigniew Warkocki, et al. Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s. Cell. 2018 Sep 6;174(6):1537-1548.e29. [Content Brief]

[4]. Kathryn E Callahan, et al. Polymerization and nucleic acid-binding properties of human L1 ORF1 protein. Nucleic Acids Res. 2012 Jan;40(2):813-27. [Content Brief]

[5]. Marie MacLennan, et al. Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. Elife. 2017 Aug 14;6:e26152. [Content Brief]

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