Lipoxygenase (LOX)

Definition:

Lipoxygenases (LOX) are non-heme iron-containing enzymes that catalyze regio- and stereo-selective dioxygenation of polyunsaturated fatty acids (PUFA). Mammalian LOXs participate in the eicosanoid cascade during the inflammatory response, using preferentially arachidonic acid (AA) as substrate, for the synthesis of leukotrienes (LT) and other oxidized-lipid intermediaries.

References:

[1]. Wood I, et al. Structural considerations on lipoxygenase function, inhibition and crosstalk with nitric oxide pathways. Biochimie. 2020 Nov;178:170-180. [Content Brief]

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