Major facilitator superfamily domain-containing protein 12

Definition:

Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation. In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation. Also catalyzes import of cysteine into lysosomes in non-pigmented cells.

References:

[1]. Charles H Adelmann, et al. MFSD12 mediates the import of cysteine into melanosomes and lysosomes. Nature. 2020 Dec;588(7839):699-704. [Content Brief]

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