Mass Spectrometry Studies of Complexes

Definition:

Mass Spectrometry Studies of Complexes use mass spectrometry to analyze the stoichiometry and transient binding of subunits in macromolecular complexes. This method preserves the integrity of the complex and can be used to study complex dissociation patterns under different experimental conditions or the effect of collision energy on subunit separation, making it suitable for dynamic complex and transient protein network analysis.

References:

[1]. Mehmood S, et al. Mass spectrometry of protein complexes: from origins to applications. Annu Rev Phys Chem. 2015 Apr;66:453-74. [Content Brief]

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