Matrix extracellular phosphoglycoprotein

Definition:

Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation.

References:

[1]. Adele L Boskey, et al. MEPE's diverse effects on mineralization. Calcif Tissue Int. 2010 Jan;86(1):42-6. [Content Brief]

[2]. K A Staines, et al. MEPE is a novel regulator of growth plate cartilage mineralization. Bone. 2012 Sep;51(3):418-30. [Content Brief]

[3]. P S N Rowe, et al. MEPE has the properties of an osteoblastic phosphatonin and minhibin. Bone. 2004 Feb;34(2):303-19. [Content Brief]

[4]. Joanne Marks, et al. Matrix extracellular phosphoglycoprotein inhibits phosphate transport. J Am Soc Nephrol. 2008 Dec;19(12):2313-20. [Content Brief]

[5]. Aline Martin, et al. Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology. 2008 Apr;149(4):1757-72. [Content Brief]

[6]. Xi Wei, et al. The effect of matrix extracellular phosphoglycoprotein and its downstream osteogenesis-related gene expression on the proliferation and differentiation of human dental pulp cells. J Endod. 2012 Mar;38(3):330-8. [Content Brief]

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