MAU2 chromatid cohesion factor homolog

Definition:

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin. Plays a role in sister chromatid cohesion and normal progression through prometaphase.

References:

[1]. Vlad C Seitan, et al. Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. PLoS Biol. 2006 Jul;4(8):e242. [Content Brief]

[2]. Christopher Bot, et al. Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage. J Cell Sci. 2017 Mar 15;130(6):1134-1146. [Content Brief]

[3]. Vladimir P Bermudez, et al. In vitro loading of human cohesin on DNA by the human Scc2-Scc4 loader complex. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9366-71. [Content Brief]

[4]. Erwan Watrin, et al. Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol. 2006 May 9;16(9):863-74. [Content Brief]

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