Membrane-associated progesterone receptor component 1

Definition:

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins.

References:

[1]. Daniel Kaluka, et al. Spectroscopic and mutagenesis studies of human PGRMC1. Biochemistry. 2015 Mar 3;54(8):1638-47. [Content Brief]

[2]. Robert B Piel 3rd, et al. A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of Ferrochelatase. Biochemistry. 2016 Sep 20;55(37):5204-17. [Content Brief]

[3]. Chang S Ryu, et al. Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450. Front Pharmacol. 2017 Mar 27;8:159. [Content Brief]

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