Meningococcal infection

Definition:

Neisseria meningitidis is a gram-negative bacterial pathogen that specifically infects humans. It is a frequent asymptomatic colonizer of the human upper respiratory tract, and most adults are resistant to infection through acquired immunity. In susceptible individuals, it causes meningococcal meningitis and severe septicemia.

References:

[1]. Caroline Foster, et al. New therapies and vaccines for bacterial meningitis. Expert Opin Investig Drugs. 2002 Aug;11(8):1051-60. [Content Brief]

[2]. Marco A P Sáfadi, et al. Epidemiology and prevention of meningococcal disease: a critical appraisal of vaccine policies. Expert Rev Vaccines. 2011 Dec;10(12):1717-30. [Content Brief]

[3]. Mumtaz Virji, et al. Pathogenic neisseriae: surface modulation, pathogenesis and infection control. Nat Rev Microbiol. 2009 Apr;7(4):274-86. [Content Brief]

[4]. Ram Yogev, et al. Meningococcal disease: the advances and challenges of meningococcal disease prevention. Hum Vaccin. 2011 Aug;7(8):828-37. [Content Brief]

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