Mesoderm induction early response protein 1

Definition:

Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

References:

[1]. Zhihu Ding, et al. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. Mol Cell Biol. 2003 Jan;23(1):250-8. [Content Brief]

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