Metallo-beta-lactamase domain-containing protein 1

Definition:

Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.

References:

[1]. Ilaria Pettinati, et al. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. Elife. 2018 Dec 3;7:e39865. [Content Brief]

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