Methicillin-resistant Staphylococcal aureus (MRSA) infection

Definition:

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major multidrug-resistant bacteria which have become endemic in the hospital environment, particularly in intensive care units (ICUs). Originally limited to the hospital setting, MRSA is a growing cause of infections in the community. Community-associated MRSA (CA-MRSA) strains are genetically different from MRSA strains originating in the hospital. Its increase in the community is of concern because CA-MRSA strains appear to be highly virulent, and colonization with CA-MRSA is often undetected in hospitalized patients, which can facilitate its potential for becoming resistant to multiple antibiotics. Health care-associated MRSA (HA-MRSA) is usually associated with pneumonia, urinary tract, blood stream, and surgical wound infections. In contrast, CA-MRSA strains are overwhelmingly associated with skin and soft tissue infections.

References:

[1]. David K Henderson, et al. Managing methicillin-resistant staphylococci: a paradigm for preventing nosocomial transmission of resistant organisms. Am J Infect Control. 2006 Jun;34(5 Suppl 1):S46-54: discussion S64-73. [Content Brief]

[2]. Michael Otto, et al. Basis of virulence in community-associated methicillin-resistant Staphylococcus aureus. Annu Rev Microbiol. 2010;64:143-62. [Content Brief]

[3]. Temujin T Chavez, et al. Health care-associated MRSA versus community-associated MRSA. Dis Mon. 2008 Dec;54(12):763-8. [Content Brief]

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