Methionine aminopeptidase 1D, mitochondrial

Definition:

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.

References:

[1]. M Leszczyniecka, et al. MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. Oncogene. 2006 Jun 8;25(24):3471-8. [Content Brief]

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