Microtubule-associated tyrosine carboxypeptidase 1

Definition:

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8. Recognizes adjacent tubulin dimers along the same protofilament.

References:

[1]. Lisa Landskron, et al. Posttranslational modification of microtubules by the MATCAP detyrosinase. Science. 2022 May 20;376(6595):eabn6020. [Content Brief]

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