Mitochondrial amidoxime reducing component 2

Definition:

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.

References:

[1]. Jürke Kotthaus, et al. Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC). Biochem J. 2011 Jan 15;433(2):383-91. [Content Brief]

[2]. Gudrun Ott, et al. Functional characterization of protein variants encoded by nonsynonymous single nucleotide polymorphisms in MARC1 and MARC2 in healthy Caucasians. Drug Metab Dispos. 2014 Apr;42(4):718-25. [Content Brief]

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