Mitochondrial glycine transporter

Definition:

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.; Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

References:

[1]. Paola Lunetti, et al. Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia. J Biol Chem. 2016 Sep 16;291(38):19746-59. [Content Brief]

[2]. Duane L Guernsey, et al. Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet. 2009 Jun;41(6):651-3. [Content Brief]

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