Mitochondrial import receptor subunit TOM40 homolog

Definition:

Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria.

References:

[1]. Adam D Humphries, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005 Mar 25;280(12):11535-43. [Content Brief]

[2]. Takushi Namba, et al. BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites. Sci Adv. 2019 Jun 12;5(6):eaaw1386. [Content Brief]

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