Modulator of apoptosis 1

Definition:

Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex.

References:

[1]. Kuan Onn Tan, et al. MAP-1 is a mitochondrial effector of Bax. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14623-8. [Content Brief]

[2]. Hao-Chun Chang, et al. The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Autophagy. 2021 Nov;17(11):3725-3739. [Content Brief]

[3]. Chong Teik Tan, et al. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. EMBO Rep. 2021 Jan 7;22(1):e50854. [Content Brief]

[4]. Shairaz Baksh, et al. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Mol Cell. 2005 Jun 10;18(6):637-50. [Content Brief]

[5]. K O Tan, et al. MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J Biol Chem. 2001 Jan 26;276(4):2802-7. [Content Brief]

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