Mucin-5AC

Definition:

Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).

References:

[1]. Juan Perez-Vilar, et al. C-Mannosylation of MUC5AC and MUC5B Cys subdomains. Glycobiology. 2004 Apr;14(4):325-37. [Content Brief]

[2]. Jeroen H B Van de Bovenkamp, et al. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. Helicobacter. 2003;8(5):521-32. [Content Brief]

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