Mucin-6

Definition:

May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

References:

[1]. A E Bartman, et al. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues. J Pathol. 1998 Dec;186(4):398-405. [Content Brief]

[2]. C J Reid, et al. Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts. J Histochem Cytochem. 1999 Jun;47(6):817-22. [Content Brief]

[3]. Henrik Nordman, et al. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. Biochem J. 2002 May 15;364(Pt 1):191-200. [Content Brief]

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