Multiple epidermal growth factor-like domains protein 10

Definition:

Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.

References:

[1]. Yannick Hamon, et al. Cooperation between engulfment receptors: the case of ABCA1 and MEGF10. PLoS One. 2006 Dec 27;1(1):e120. [Content Brief]

[2]. Thoudam Debraj Singh, et al. MEGF10 functions as a receptor for the uptake of amyloid-β. FEBS Lett. 2010 Sep 24;584(18):3936-42. [Content Brief]

[3]. Emiko Suzuki, et al. The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern. Exp Cell Res. 2007 Jul 1;313(11):2451-64. [Content Brief]

[4]. Tal Iram, et al. Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes. J Neurosci. 2016 May 11;36(19):5185-92. [Content Brief]

[5]. Madhurima Saha, et al. Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions. Hum Mol Genet. 2017 Aug 1;26(15):2984-3000. [Content Brief]

[6]. Clare V Logan, et al. Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD). Nat Genet. 2011 Nov 20;43(12):1189-92. [Content Brief]

[7]. Emiko Suzuki, et al. MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation. Exp Cell Res. 2007 Oct 15;313(17):3729-42. [Content Brief]

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