Muscle hypertrophy

Definition:

Muscle hypertrophy (MSLHP) is defined as an increase in muscle mass, as a result of an increase in the size of pre-existing muscle fibers. A myostatin mutation in a child with muscle hypertrophy has been identified. Myostatin, a member of the TGF-beta superfamily, is a potent negative regulator of skeletal muscle growth. Myostatin inactivation can induce muscle hypertrophy.

References:

[1]. Branimir Catipović, et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med. 2004 Sep 2;351(10):1030-1; author reply 1030-1. [Content Brief]

[2]. David J Glass, et al. Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol. 2005 Oct;37(10):1974-84. [Content Brief]

[3]. J Rodriguez, et al. Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways. Cell Mol Life Sci. 2014 Nov;71(22):4361-71. [Content Brief]

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