Muscleblind-like protein 3

Definition:

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.

References:

[1]. Thai H Ho, et al. Muscleblind proteins regulate alternative splicing. EMBO J. 2004 Aug 4;23(15):3103-12. [Content Brief]

[2]. Rachel M Squillace, et al. Inhibition of muscle differentiation by the novel muscleblind-related protein CHCR. Dev Biol. 2002 Oct 1;250(1):218-30. [Content Brief]

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