Myb-related protein A

Definition:

Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity).

References:

[1]. J Golay, et al. The human A-myb protein is a strong activator of transcription. Oncogene. 1994 Sep;9(9):2469-79. [Content Brief]

[2]. X P Ma, et al. DNA binding and transactivation activity of A-myb, a c-myb-related gene. Cancer Res. 1994 Dec 15;54(24):6512-6. [Content Brief]

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