Myelin protein P0

Definition:

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.

References:

[1]. A Lagueny, et al. Peripheral myelin modification in CMT1B correlates with MPZ gene mutations. Neuromuscul Disord. 1999 Oct;9(6-7):361-7. [Content Brief]

[2]. Marina Grandis, et al. Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations. Hum Mol Genet. 2008 Jul 1;17(13):1877-89. [Content Brief]

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