N-terminal EF-hand calcium-binding protein 2

Definition:

May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.

References:

[1]. Laia Canela, et al. The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. J Neurochem. 2009 Oct;111(2):555-67. [Content Brief]

[2]. Laia Canela, et al. The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Mol Cell Neurosci. 2007 Sep;36(1):1-12. [Content Brief]

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