NADPH oxidase 5

Definition:

Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.

References:

[1]. B Bánfi, et al. A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem. 2001 Oct 5;276(40):37594-601. [Content Brief]

[2]. Rachida S BelAiba, et al. NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med. 2007 Feb 15;42(4):446-59. [Content Brief]

[3]. Sukhdev S Brar, et al. NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol. 2003 Aug;285(2):C353-69. [Content Brief]

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