Negative elongation factor E

Definition:

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II.

References:

[1]. Seychelle M Vos, et al. Architecture and RNA binding of the human negative elongation factor. Elife. 2016 Jun 10;5:e14981. [Content Brief]

[2]. Y Yamaguchi, et al. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell. 1999 Apr 2;97(1):41-51. [Content Brief]

[3]. Bryan A Gibson, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353(6294):45-50. [Content Brief]

[4]. Jampani Nageswara Rao, et al. NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding. Biochemistry. 2008 Mar 25;47(12):3756-61. [Content Brief]

[5]. Takashi Narita, et al. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Mol Cell Biol. 2003 Mar;23(6):1863-73. [Content Brief]

[6]. Malini Natarajan, et al. Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem. 2013 Sep 6;288(36):25995-26003. [Content Brief]

[7]. Yuki Yamaguchi, et al. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol. 2002 May;22(9):2918-27. [Content Brief]

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