Nucleoporin NDC1

Definition:

Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.

References:

[1]. Fabrizia Stavru, et al. NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. J Cell Biol. 2006 May 22;173(4):509-19. [Content Brief]

[2]. Jörg Mansfeld, et al. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Mol Cell. 2006 Apr 7;22(1):93-103. [Content Brief]

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