Nucleoporin NUP42

Definition:

Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.; (Microbial infection) In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope.

References:

[1]. Erwann Le Rouzic, et al. Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1. J Biol Chem. 2002 Nov 22;277(47):45091-8. [Content Brief]

[2]. Frederic Kendirgi, et al. Interaction between the shuttling mRNA export factor Gle1 and the nucleoporin hCG1: a conserved mechanism in the export of Hsp70 mRNA. Mol Biol Cell. 2005 Sep;16(9):4304-15. [Content Brief]

[3]. Y Strahm, et al. The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p. EMBO J. 1999 Oct 15;18(20):5761-77. [Content Brief]

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