Oligonucleotide

Definition:

Oligonucleotides are short DNA or RNA linear molecules. Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing.

References:

[1]. Roberts TC, et al. Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694. [Content Brief]

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