Ovarian cancer G-protein coupled receptor 1

Definition:

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).

References:

[1]. Marie-Gabrielle Ludwig, et al. Proton-sensing G-protein-coupled receptors. Nature. 2003 Sep 4;425(6953):93-8. [Content Brief]

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