P2X purinoceptor 4

Definition:

Receptor for extracellularly released ATP acting as a ligand-gated ion channel that plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Participates also in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC. Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity).

References:

[1]. Chakib Hamoudi, et al. The Purinergic Receptor P2X4 Promotes Th17 Activation and the Development of Arthritis. J Immunol. 2022 Mar 1;208(5):1115-1127. [Content Brief]

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