Paired-like homeodomain transcription factor LEUTX

Definition:

[Isoform 1]: Paired-like homeobox transcription factor involved in embryogenesis. May act as a regulator of embryo genome activation. Binds to a 36 bp DNA elements containing a 5'-TAATCC-3' sequence motif, referred to as EEA motif (EGA-enriched Alu-motif), present in the promoters of target genes activated in early embryos.; [Isoform 2]: Inactive transcriptional activity.

References:

[1]. Shintaro Katayama, et al. Phylogenetic and mutational analyses of human LEUTX, a homeobox gene implicated in embryogenesis. Sci Rep. 2018 Nov 27;8(1):17421. [Content Brief]

[2]. Eeva-Mari Jouhilahti, et al. The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. Development. 2016 Oct 1;143(19):3459-3469. [Content Brief]

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