Palladin

Definition:

Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.

References:

[1]. Mikko Rönty, et al. Molecular analysis of the interaction between palladin and alpha-actinin. FEBS Lett. 2004 May 21;566(1-3):30-4. [Content Brief]

[2]. O M Mykkänen, et al. Characterization of human palladin, a microfilament-associated protein. Mol Biol Cell. 2001 Oct;12(10):3060-73. [Content Brief]

[3]. Mikko Rönty, et al. Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling. Exp Cell Res. 2007 Jul 15;313(12):2575-85. [Content Brief]

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