Pancreatic ductal adenocarcinomas (PDAC)

Definition:

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by a poor prognosis and high mortality rate.The typical histopathology of PDAC comprises clusters of moderately-to-poorly differentiated cancer cells embedded within an exuberant desmoplastic stroma, consisting of Extracellular matrix (ECM), Cancer-associated fibroblasts (CAFs) and immune cells.

References:

[1]. Yunzhen Qian, et al. Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol. 2020 Oct 2;13(1):130. [Content Brief]

[2]. Jincheng Han, et al. Single-cell RNA sequencing in pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):451-452. [Content Brief]

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