Pantothenate kinase 2, mitochondrial

Definition:

[Isoform 1]: Mitochondrial isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. Required for angiogenic activity of umbilical vein of endothelial cells (HUVEC).; [Isoform 4]: Cytoplasmic isoform that catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.

References:

[1]. Paul T Kotzbauer, et al. Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2. J Neurosci. 2005 Jan 19;25(3):689-98. [Content Brief]

[2]. Roberta Leonardi, et al. Localization and regulation of mouse pantothenate kinase 2. FEBS Lett. 2007 Oct 2;581(24):4639-44. [Content Brief]

[3]. Francesca Pagani, et al. Silencing of pantothenate kinase 2 reduces endothelial cell angiogenesis. Mol Med Rep. 2018 Nov;18(5):4739-4746. [Content Brief]

[4]. Roberta Leonardi, et al. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1494-9. [Content Brief]

[5]. Yong-Mei Zhang, et al. Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration. J Biol Chem. 2006 Jan 6;281(1):107-14. [Content Brief]

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