Parathyroid hormone/parathyroid hormone-related peptide receptor

Definition:

Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

References:

[1]. H Schneider, et al. Cloning and functional expression of a human parathyroid hormone receptor. Eur J Pharmacol. 1993 Jul 15;246(2):149-55. [Content Brief]

[2]. Junko Shimomura-Kuroki, et al. Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia. Odontology. 2017 Apr;105(2):150-154. [Content Brief]

[3]. Augen A Pioszak, et al. Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. J Biol Chem. 2010 Apr 16;285(16):12435-44. [Content Brief]

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