Patched domain-containing protein 4

Definition:

Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells.

References:

[1]. Jon H Chung, et al. A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. J Biol Chem. 2014 Nov 21;289(47):33020-31. [Content Brief]

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