PDZ domain-containing protein 11

Definition:

Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-binding protein TSPAN33.

References:

[1]. Jimit Shah, et al. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Cell Rep. 2018 Nov 20;25(8):2132-2147.e7. [Content Brief]

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